2021 Mercedes-Benz E-Class fuel economy
The 2021 Mercedes-Benz E-Class is rated at 18–26 MPG combined by the EPA, from 18 MPG (4.0 L 8-cyl turbo, Automatic 9-spd, 4-Wheel Drive) to 26 MPG (3.0 L 6-cyl turbo, Automatic 9-spd, 4-Wheel Drive). EPA size class: Midsize Cars, Subcompact Cars, Midsize Station Wagons.
MPG by version
| Version | City | Hwy | Comb. | L/100 km | UK MPG | Fuel cost/yr* |
|---|---|---|---|---|---|---|
| E450 4matic 3.0 L 6-cyl turbo, Automatic 9-spd, 4-Wheel Drive · Hybrid · Premium Gasoline | 23 | 30 | 26 | 9.0 | 31 | $3,150 |
| E450 Coupe 3.0 L 6-cyl turbo, Automatic 9-spd, Rear-Wheel Drive · Hybrid · Premium Gasoline | 23 | 31 | 26 | 9.0 | 31 | $3,150 |
| AMG E53 4matic Plus 3.0 L 6-cyl, Automatic 9-spd, 4-Wheel Drive · Hybrid · Premium Gasoline | 22 | 29 | 25 | 9.4 | 30 | $3,300 |
| E350 2.0 L 4-cyl turbo, Automatic 9-spd, Rear-Wheel Drive · Premium Gasoline | 22 | 31 | 25 | 9.4 | 30 | $3,300 |
| E350 4matic 2.0 L 4-cyl turbo, Automatic 9-spd, 4-Wheel Drive · Premium Gasoline | 22 | 30 | 25 | 9.4 | 30 | $3,300 |
| E450 4matic Convertible 3.0 L 6-cyl turbo, Automatic 9-spd, 4-Wheel Drive · Hybrid · Premium Gasoline | 23 | 29 | 25 | 9.4 | 30 | $3,300 |
| E450 4matic Coupe 3.0 L 6-cyl turbo, Automatic 9-spd, 4-Wheel Drive · Hybrid · Premium Gasoline | 23 | 30 | 25 | 9.4 | 30 | $3,300 |
| E450 Convertible 3.0 L 6-cyl turbo, Automatic 9-spd, Rear-Wheel Drive · Hybrid · Premium Gasoline | 23 | 30 | 25 | 9.4 | 30 | $3,300 |
| AMG E53 4matic Plus Coupe 3.0 L 6-cyl, Automatic 9-spd, 4-Wheel Drive · Hybrid · Premium Gasoline | 21 | 28 | 24 | 9.8 | 29 | $3,400 |
| E450 4matic All-Terrain (wagon) 3.0 L 6-cyl turbo, Automatic 9-spd, 4-Wheel Drive · Hybrid · Premium Gasoline | 22 | 28 | 24 | 9.8 | 29 | $3,400 |
| AMG E53 4matic Plus Convertible 3.0 L 6-cyl, Automatic 9-spd, 4-Wheel Drive · Hybrid · Premium Gasoline | 21 | 27 | 23 | 10.2 | 28 | $3,550 |
| AMG E63 S 4matic Plus 4.0 L 8-cyl turbo, Automatic 9-spd, 4-Wheel Drive · Premium Gasoline | 16 | 23 | 18 | 13.1 | 22 | $4,550 |
| AMG E63 S 4matic Plus (SW) 4.0 L 8-cyl turbo, Automatic 9-spd, 4-Wheel Drive · Premium Gasoline | 16 | 23 | 18 | 13.1 | 22 | $4,550 |
* EPA estimate of yearly fuel (or electricity) cost for 15,000 miles with 55 % city driving, at the fuel prices EPA used for this model year. Use the fuel cost comparison with your own mileage and prices.
About these numbers
EPA ratings come from standard laboratory tests adjusted to reflect real-world driving, so they are best for comparing vehicles. Your own figure will vary with speed, temperature, load, tires and driving style — measure it with the MPG calculator. If you have fitted larger tires, correct the reading with the tire size and fuel economy calculator.
Source: U.S. Environmental Protection Agency and U.S. Department of Energy, fueleconomy.gov. Original data (downloaded 2026-09-29). Data processed by us; errors in processing are ours, not the publisher's.