2021 Mercedes-Benz S-Class fuel economy
The 2021 Mercedes-Benz S-Class is rated at 17–24 MPG combined by the EPA, from 17 MPG (4.0 L 8-cyl turbo, Automatic 9-spd, 4-Wheel Drive) to 24 MPG (3.0 L 6-cyl, Automatic 9-spd, 4-Wheel Drive). EPA size class: Large Cars, Compact Cars, Subcompact Cars.
MPG by version
| Version | City | Hwy | Comb. | L/100 km | UK MPG | Fuel cost/yr* |
|---|---|---|---|---|---|---|
| S500 4matic 3.0 L 6-cyl, Automatic 9-spd, 4-Wheel Drive · Hybrid · Premium Gasoline | 20 | 29 | 24 | 9.8 | 29 | $3,400 |
| S560 4matic Coupe 4.0 L 8-cyl turbo, Automatic 9-spd, 4-Wheel Drive · Premium Gasoline | 16 | 26 | 20 | 11.8 | 24 | $4,100 |
| S560 Convertible 4.0 L 8-cyl turbo, Automatic 9-spd, Rear-Wheel Drive · Premium Gasoline | 16 | 26 | 20 | 11.8 | 24 | $4,100 |
| S580 4matic 4.0 L 8-cyl turbo, Automatic 9-spd, 4-Wheel Drive · Hybrid · Premium Gasoline | 17 | 25 | 20 | 11.8 | 24 | $4,100 |
| AMG S63 4matic Plus Coupe 4.0 L 8-cyl turbo, Automatic 9-spd, 4-Wheel Drive · Premium Gasoline | 16 | 26 | 19 | 12.4 | 23 | $4,350 |
| S580 4matic Maybach 4.0 L 8-cyl turbo, Automatic 9-spd, 4-Wheel Drive · Hybrid · Premium Gasoline | 16 | 24 | 19 | 12.4 | 23 | $4,350 |
| AMG S63 4matic Plus Convertible 4.0 L 8-cyl turbo, Automatic 9-spd, 4-Wheel Drive · Premium Gasoline | 14 | 24 | 17 | 13.8 | 20 | $4,850 |
* EPA estimate of yearly fuel (or electricity) cost for 15,000 miles with 55 % city driving, at the fuel prices EPA used for this model year. Use the fuel cost comparison with your own mileage and prices.
About these numbers
EPA ratings come from standard laboratory tests adjusted to reflect real-world driving, so they are best for comparing vehicles. Your own figure will vary with speed, temperature, load, tires and driving style — measure it with the MPG calculator. If you have fitted larger tires, correct the reading with the tire size and fuel economy calculator.
Source: U.S. Environmental Protection Agency and U.S. Department of Energy, fueleconomy.gov. Original data (downloaded 2026-09-29). Data processed by us; errors in processing are ours, not the publisher's.