2022 Mercedes-Benz S-Class fuel economy
The 2022 Mercedes-Benz S-Class is rated at 15–24 MPG combined by the EPA, from 15 MPG (6.0 L 12-cyl turbo, Automatic 9-spd, All-Wheel Drive) to 24 MPG (3.0 L 6-cyl, Automatic 9-spd, All-Wheel Drive). EPA size class: Large Cars.
MPG by version
| Version | City | Hwy | Comb. | L/100 km | UK MPG | Fuel cost/yr* |
|---|---|---|---|---|---|---|
| S500 4matic 3.0 L 6-cyl, Automatic 9-spd, All-Wheel Drive · Hybrid · Premium Gasoline | 21 | 30 | 24 | 9.8 | 29 | $3,400 |
| S580 4matic 4.0 L 8-cyl turbo, Automatic 9-spd, All-Wheel Drive · Hybrid · Premium Gasoline | 16 | 25 | 19 | 12.4 | 23 | $4,350 |
| S580 4matic Maybach 4.0 L 8-cyl turbo, Automatic 9-spd, All-Wheel Drive · Hybrid · Premium Gasoline | 15 | 24 | 18 | 13.1 | 22 | $4,550 |
| Maybach S680 4matic 6.0 L 12-cyl turbo, Automatic 9-spd, All-Wheel Drive · Premium Gasoline | 12 | 21 | 15 | 15.7 | 18 | $5,500 |
* EPA estimate of yearly fuel (or electricity) cost for 15,000 miles with 55 % city driving, at the fuel prices EPA used for this model year. Use the fuel cost comparison with your own mileage and prices.
About these numbers
EPA ratings come from standard laboratory tests adjusted to reflect real-world driving, so they are best for comparing vehicles. Your own figure will vary with speed, temperature, load, tires and driving style — measure it with the MPG calculator. If you have fitted larger tires, correct the reading with the tire size and fuel economy calculator.
Source: U.S. Environmental Protection Agency and U.S. Department of Energy, fueleconomy.gov. Original data (downloaded 2026-09-29). Data processed by us; errors in processing are ours, not the publisher's.